Certain people should not take inositol supplements at all:
- Women who are pregnant or breastfeeding
At present, a recommended daily intake of inositol for women who are pregnant or breastfeeding has not been established, so safe levels of inositol have not been established for women who are pregnant or breastfeeding, who should instead get their inositol from foods.
Certain people should only take inositol supplements without first consulting their doctor for advice:
- People with an anxiety disorder
People who have any type of anxiety disorder may experience a worsening of their condition if the intake of inositol supplements is high.
- People with a sleep disorder
People that have a sleep disorder (such as insomnia) may may experience a worsening of their condition if the intake of inositol supplements is high.
- People with diabetes (and peripheral neuropathy)
People that have diabetes, especially if they have peripheral neuropathy symptoms (tingling and pain in the extremities) need to ensure the amount of inositol taken is adequate and does not make their symptoms worse. Inositol supplementation in people with diabetic neuropathy need to be monitored while they are taking it, to determine how effective it is as a treatment for their condition.
Women who are pregnant or breastfeeding should not take inositol supplements
Toxic Levels of Inositol
Inositol is essentially non-toxic, even when it is taken at high doses. The only side effects occur when doses of inositol are greater than 0.5g per kg of body weight per day. Overdosage and toxicity is more likely to occur from taking too many supplements, whereas dietary intake of inositol is highly unlikely to cause overdosage.
Overdosage and Toxicity Symptoms
If inositol is taken above 0.5g per kg of body weight, it can cause the following toxicity symptoms:
- Increased excretion of creatine
People experiencing any of the above toxicity symptoms should discontinue their inositol supplements and seek medical advice.