Histidine Cautions
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In general, histidine supplements produce no major problems for otherwise healthy individuals, but certain people with the following health conditions should not take histidine:
- People with severe allergies
- People with manic depression (bipolar disorder)
- People with liver or kidney disease
- People with any type of medical condition
- Women who are pregnant or breastfeeding
People with the above health conditions should consult their doctor for advice if they want to take histidine supplements, as the histidine could make these conditions worse.
In general, histidine supplements produce no major problems for otherwise healthy individuals, but people with certain health conditions should not take histidine
Toxic Levels of Histidine
Histidine is toxic at doses greater than 5% of the total diet per day.
Overdosage and Toxicity Symptoms
Toxicity of histidine can produce the following symptoms:
- Decreased levels of isoleucine in the brain
- Decreased levels of leucine in the brain
- Decreased levels of phenylalanine in the brain
- Decreased levels of tyrosine in the brain
- Increased histidine levels in the brain
- Reduced growth
Toxicity of histidine is greatly reduced if it is also supplemented with the following nutrients at the same time:
- Copper
- Folic acid (folate)
- Methionine
- Vitamin A
Supplementing histidine together with copper, folic acid (folate), methionine and vitamin A greatly reduces its toxicity.