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Vitamin B1 (Thiamine) Interactions

The following are the medications and supplements that are more likely to cause a reaction with vitamin B1 (thiamin) supplements:

  • Antacids
    People taking antacids may have decreased absorption and increased excretion of vitamin B1 (thiamin) and may require supplementation.
  • Antibiotics
    People taking antibiotics may have lowered vitamin B1 (thiamin) levels, due to the action of the antibiotics blocking absorption of the vitamin B1 (thiamin). People taking antibiotics may need to be supplemented with vitamin B1 (thiamin).
  • Barbituates
    People taking barbituates may have decreased absorption and increased excretion of vitamin B1 (thiamin) and may require supplementation.
  • Diuretics
    Loop and thiazide diuretics cause decreased vitamin B1 (thiamin) levels by increasing the excretion and decreasing the absorption this vitamin. People taking these medications over the longer term may require supplementation.
  • Muscle relaxants used during surgery
    Muscle relaxants that are used during surgery can produce excessive muscle relaxation if taken with vitamin B1 (thiamin) at the same time. People about to undergo surgery need to stop taking vitamin B1 (thiamin) supplements at least 3-4 days prior to surgery to avoid this adverse effect.
Vitamin B1 (Thiamine) interacts with a number of medications and supplements
  • Oral contraceptives
    Women taking oral contraceptives may have lowered vitamin B1 (thiamin) levels, due to the action of the oral contraceptives blocking absorption of the vitamin B1 (thiamin). People taking antibiotics may need to be supplemented with vitamin B1 (thiamin).
  • Quercetin
    The bioflavonoid quercetin can block the absorption and usage of vitamin B1 (thiamin), as quercetin is an antagonist to vitamin B1 (thiamin), so supplementation may be required.
  • Sulfa medications
    People taking Sulfa medications may have lowered vitamin B1 (thiamin) levels, due to the action of the Sulfa medications blocking absorption of the vitamin B1 (thiamin). People taking Sulfa medications may need to be supplemented with vitamin B1 (thiamin).
  • Thyroxine
    The thyroid hormone thyroxine may have reduced levels of stored vitamin B1 (thiamin) in the liver and increased excretion of vitamin B1 (thiamin) too, which could require supplementation.
  • Wernicke's encephalopathy treatment
    People undergoing Wernicke's encephalopathy treatment should take the vitamin B1 (thiamin) supplements prior to taking glucose as it could interfere with the glucose absorption if taken together.

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